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Medication Safety in Pregnancy

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EMA's first public hearing: giving EU citizens a voice to help reduce the risk of valproate



For EUROmediSAFE’s ongoing research on the frequency with which valproate is prescribed in Europe,click here:


For EUROmediCAT’s research results on the risks of valproate, see Jentink J, Loane M, Dolk H, Barisic I, Garne E, Morris J, de Jong-van den Berg L and EUROCAT Antiepileptic Study Working Group (2010). Valproic acid monotherapy in pregnancy and major congenital malformations. The New England Journal of Medicine. 362(23): 2185-2193. (Full Text)


Gastroschisis Article and Published Article

Given JE, Loane M, Garne E, Nelen V, Barisic I, Randrianaivo H, Khoshnood B, Wiesel A, Rissmann A, Lynch C, Neville AJ, Pierini A, Bakker M, Klungsoyr K, Latos Bielenska A, et al. (2017). “Gastroschisis in Europe - A Case-malformed-Control Study of Medication and Maternal Illness during Pregnancy as Risk Factors”. Paediatric and Perinatal Epidemiology. Available at: